1989 Volume 35 Issue 7 Pages 1902-1908
A 60 year-old male patient with Mikulicz's disease was reported
He had a marked symmetrical painless enlargement of the bilateral lacrimal, parotid, submandibular and sublingual glands. His face showes the typical appearance from the enlargement of these glands in this disease.
Laboratory examinations revealed immunological abnormality such as increased gamma globulin fraction and elevation of IgG fraction. Sialogram of his parotid and submandibular glands showed some part of shadowless pattern in the parenchyma.
Histopathologically his lacrimal, parotid and submandibular glands revealed both atrophy or loss of acinar tissue with lymphoid infiltration and ductal changes including the development of epimyothelial islands.
This patient is presently under control by administration of prednisolone
Mikulicz's disease accounted for 16 cases reported in Japanese literature for the period of 1973-1988.