Fundamental study of combination therapy with UFT and irradiation

Abstract

The combined effects of UFT and irradiation on Ehrlich ascites tumor and malignant tumor lines derived from oral and maxillofacial region transplanted into nude mice were observed.
As for the results, a significant elongation of mean survival time of mice bearing Ehrlich ascites tumor was observed when high-dose irradiation (8 Gy, 10 Gy) was combined with 5-FU or UFT. But significant enhancement of antitumor effect was observed in the combination with UFT and low-dose irradiation (2 Gy, 4 Gy).
With regard to the malignant tumor lines, no remarkable enhancement of antitumor effect were observed in three squamous cell carcinoma lines. 011 the other hand, synergistic inhibitions of tumor growth were observed when combined with UFT 30 tog/kg and 4 Gy in three adenocarcinoma lines derived from salivary glands.
There was inconsiderable decrease in body weights in treated nude mice.
Therefore, it is considered that the combination therapy UFT and irradiation is useful for the treatment of oral carcinomas, especially salivary gland carcinomas which are thought to be resistant against radiotherapy or chemotherapy.