家兎VX2舌癌に対するRhodamine 123の抗腫瘍効果に関する実験的研究

抄録

The cationic lipophilic compound, rhodamine 123, has a unique cytotoxic mechanism of action which is dependent on mitochondria-specific affinity of this fluorescent dye. The author investigated the anticancer activity of rhodamine 123 against a VX2 tongue cancer in rabbits. The following results were obtained:
1) In normal rabbits injected with rhodamine 123 in doses equal to or lower than 10 mg/kg (i.v.), marked systemic toxic effects on body weight, peripheral blood findings, blood chemical examinations, and histopathological findings were not noted.
2) In regard to the anticancer activity of rhodamine 123, groups of rabbits treated with rhodamine 123 showed significant inhibition of VX2 cancer growth conpared with a control group.
3) The anticancer activity of rhodamine 123 against VX2 cancer was markedly enhanced by conbined use with 2-deoxyglucose.
4) Histopathologically, necrosis and disappearance of VX2 cancer cells, atrophy ofmuscle fibers and fibrosis were observed in groups locally injected with rhodamine 123.
5) Ultrastructurally, mitochondrial swelling, dissolution, and disappearance of cristae were particularly remarkable in groups treated with rhodamine 123.
The results of these investigations demonstrated the anticancer activity of rhodamine 123 against a VX2 tongue cancer in rabbits, and suggested the possibility of clinically using rhodamine 123 for the treatment of oral cancer.