A case of cleidocranial dysplasia, with special reference to bone metabolism

Abstract

Cleidocranial dysplasia is a congenital systemic bone disorder characterized by delayed ossification of skull, aplastic or hypoplastic clavicle, delayed deciduous dentition, and hereditary characteristics.
A 14-year old girl came to our clinic because of many unerupted permanent teeth. She was diagnosed to he cleidocranial dysplasia based on the above characteristics.
Further examinations concerning bone metabolism revealed low serum calcitonin level, high levels of bone metabolic markers for absorption, and low lumbar spinal bone mineral density. These findings suggested abnormal bone metabolism in this patient.