Abstract
Our experience with 5 cases of non-Hodgkin's lymphoma treated by chemotherapy combined with G-CSF is reported. The patients consisted of 2 males and 3 females with a mean age of 72.6 years. The clinical Stage was classified as IE in 2 cases and I, II, IIIEin the 3 other cases. Two cases were treated with chemotherapy after irradiation and chemotherapy alone was performed in 2 cases. In the other case, recurrence after irradiation was treated with chemotherapy. The chemotherapy consisted of CHOP used in conjunction with G-CSF in all cases. With the excepton of one case in which G-CSF was not used after early phase chemotherapy was instituted, severe leukopenia was not encountered, and the treatment was completed as scheduled in all cases. The clinical response to chemotherapy was CR in 3 cases, and unknown in the 2 other cases without clinical evidence of tumor. In conclusion, chemotherapy combined with G-CSF, which proved to be effective in preventing leukopenia, is useful in the treatment of non-Hodgkin's lymphoma.
