A case of rhabdomyosarcoma in the submandibular gland is reported. A 57-year-old man consulted the Department of Oral Surgery, Dental Hospital, Hokkaido University with a chief complaint of swelling in the right submandibular region. An elastic hard, uneven mass, 40 mm in diameter, was palpated on the lateral surface of the submandibular gland. Surgical resection was carried out under a diagnosis of a submandibular gland tumor. The tumor was located in the submandibular gland, and it showed continuity to the adjacent glandular tissue. The tumor cells showed a positive reaction for vimentin, desmin, and myoglobin immunohistochemically. The tumor was diagnosed as rhabdomyosarcoma.
