Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Relationship between E-cadherin expression and prognosis in oral squamous cell carcinomas
Toshio SAKAKIMasahiro WATOYasuo MATSUNARIIsao TAMURARyuichi KAJIKozo MUSHIMOTORikiya SHIRASUAkio TANAKATetsuya SAKAKI
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1997 Volume 43 Issue 1 Pages 8-15

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Abstract

We immunohistochemically studied the relationship between E-cadherin expression and prognosis in 72 patients with primary oral squamous cell carcinoma.
E-cadherin is expressed homogeneously with a typical membranous staining pattern at cell-cell borders in normal oral epithelium. Twenty-three of the 72 tumors studied had decreased (or lost) E-cadherin expression. Decreased (or lost) expression of E-cadherin closely correlated with the cancer differentiation grade and with clinical lymph node metastasis. Moreover, decreased (or lost) E-cadherin expression correlated with shorter patient survival. However, E-cadherin expression did not correlate with T category or clinical stage.
Determination of E-cadherin expression in oral squamous cell carcinoma is therefore expected to provide useful information with regard to prognosis.

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© Japanese Society of Oral and Maxillofacial Surgeons
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