Abstract
We investigated clinically and virologically 108 patients with oral papilloma at Second Department of Oral and Maxillofacial Surgery, Osaka Dental University during the fifteen years from 1981 through 1995.
The patients consisted of 64 males and 44 females. Their ages ranged from 8 to 82 years (average age, 46.5), but the majority (80%) of them were in the fifth decade of life or older. Oral papilloma occurred most frequently in the palate (42 cases), followed by the gingiva (26 cases) and tongue (25 cases). In 84 of the 108 cases, the greatest diameter of the tumor was 10mm or less.
We examined human papillomavirus (HPV)-DNA with the use of molecular biological methods in 25 oral papillomas randomly selected from among the 108 cases. HPV-DNA of low risk type was detected in all 25 cases (HPV-6, 11), and there was no case of high-risktype HPV-DNA (HPV-16, 18, 31, 33, 52, 58).
The results indicate that the occurrence of oral papilloma is associated with HPV-6 or HPV-11 infection.
