Intra-arterial infusion therapy with urokinase and antibacterial agents for diffuse sclerosing osteomyelitis of the mandible

Abstract

Three patients with diffuse sclerosing osteomyelitis of the mandible who had been treated by intra-arterial infusion of urokinase and antibacterial agents including fosfomycin were evaluated. All patients underwent decortication at the same time. They were all free from symptoms an average of 3 years 7 months after treatment.
Urokinase and fosfomycin may cause the dissolution of biofilm, which prevents contact between antibacterial agents and causative organism. Thus, the intra-arterial infusion of urokinase, fosfomycin, and other antibacterial agents can efficiently eradicate bacteria in sclerotic bone in osteomyelitis.