日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
口腔扁平上皮癌におけるFas抗原の検出
村木 祐孝吉岡 千尋立石 晃福田 仁一羽地 達次
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1997 年 43 巻 8 号 p. 590-595

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Fas antigen is a cell surface glycoprotein that mediates apoptosis from the cell surface into the cytoplasm. A monospecific and high titer polyclonal antibody, designated as Fas D, raised against a synthetic polypeptide selected from a part of the human Fas antigen (aa 104-114) was used to detect the Fas antigen in human oral squamous cell carcinoma (SCC). Biopsy specimens of oral SCCs obtained from 38 patients were prepared, and paraffin sections were stained with the FasD antibody using an indirect immunohistochemical method.
Expression of Fas antigen was observed in 68% of the SCC cases examined. The mean age of the Fas-positive group (65.8 years old) was significantly higher than that of the Fasnegative group (55.8 years old). The specimens were also divided into well, moderately, and poorly differentiated grades according to histopathological criteria. Although the number of specimens examined was limited (24 cases) in the present study, 92% of the well differentiated SCCs stained for Fas antigen. In moderately differentiated SCCs, only 37% of the SCCs (4 out of 11) showed Fas-positive staining. No Fas-positive cells were detected in poorly differentiated SCCs although only three specimens were examined. It was found that the production of Fas antigen was related to the degree of tumor differentiation. No relationship was noted between Fas antigen expression and tumor location, T categories of the TNM classification of the UICC (1987), and cervical lymph node metastasis.
Furthermore, the clinical and pathological effects of chemotherapy in each case were evaluated with respect to the correlation with Fas antigen expression. There was a significant positive correlation between Fas antigen expression and the clinicopathological course after chemotherapy.

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