A male newborn was referred to Fujita Health University Hospital shortly after birth because of a huge tumor, 80×50×40mm in size, extending from his mouth. A great number of tumors were found throughout his body. Alimentary and respiratory difficulties and the risk of septicemia due to the oral tumor necessitated excision of the tumor when the patient was 3 days old. The tumor was composed mainly of undifferentiated, small, round cells, which had partly formed rosettes around blood vessels. A fibrous stroma and myxoid changes were found in some parts of the tumor. After histological, immunohistological, and electron-microscopical examinations, the tumor was diagnosed as an unclassified sarcoma. After an initial response to aggressive chemotherapy, most of the remaining tumors grew to the extent that it seemed incredible that the boy was still alive at nearly 1 year of age
