Mesenchymal chondrosarcoma rarely occurs in the maxillofacial region. We describe a 30-yearold man with a mesenchymal chondrosarcoma arising in the maxilla and invading the anterior-middle part of the skull base. Histopathologic examination of the tumor showed premature mesenchymal tissue and chondroid cells. The patient received induction chemotherapy with CDDP and THP-ADM and underwent wide excision of the maxilla with resection of the anterior-middle part of the skull base. He has been free of tumor for 48 months after the operation.
