We report two cases of ameloblastic fibro-odontoma, a rare odontogenic tumor. Patient 1 was a 12-year-old boy with a tumor in the right side of the mandible, and patient 2 was a 13-year-old boy with a tumor in the right side of the maxilla. The clinical diagnosis was a benign tumor of the mandible and an odontogenic tumor of the maxilla, respectively. The lesions were removed with the patients under general anesthesia. Histopathologically, the tumors showed proliferation of fibrous tissue and ameloblast-like epithelial cells. In addition, dentin-like and bone-like hard tissues were observed in the matrices of the tumors. On the basis of these findings, the tumors were diagnosed as ameloblastic fibro-odontomas. The courses of both patients were favorable with no sign of recurrence.