特発性血小板減少性紫斑病 (ITP) を合併した頬粘膜癌の手術経験

抄録

Squamous cell carcinoma of the buccal mucosa was diagnosed on biopsy. The preoperative laboratory data revealed a platelet count of 3.8 × 10⁴/mm³. These investigations suggested the presence of idiopathic thrombocytopenic purpura (ITP). For surgical therapy, it is important to maintain normal platelet counts and to control hemostasis. A preoperative high-dose of γ-globulin therapy (400mg/kg/day for 5 days) allowed operation to be performed successfully. After the surgery and without tranfusion, abnormal bleeding did not occur. The postoperative course was uneventful, and no tumor recurrence was observed.
High-dose γ-globulin therapy appears to be reasonably safe and useful in the preoperative management of surgical patients with ITP.