日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
p53タンパクが陽性であったverrucous carcinomaの1例
木下 智久保 誼修中尾 有里大杉 泰敏渡邉 岳虫本 浩三
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2003 年 49 巻 9 号 p. 533-536

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We describe our experience with a case of verrucous carcinoma arising in the upper residual ridge. A 71-year-old woman presented with a gingival swelling. On examination, we detected a granular mass in the 7-2 I region and leukoplakia lesions with an irregular surface in the 2+2 region. Radiography showed slight radiolucency of alveolar bone at the 7-2 region. Two biopsies of the mass showed papillomas. The patient underwent excision of the tumor under general anesthesia. The histopathologic diagnosis was verrucous carcinoma. We detected a tumor suppressor gene product, p53. This finding suggested that overexpression of p53 was involved in carcinogenesis. As of more than 5 years after operation, we have found no evidence of recurrence or metastasis.

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