A case of amyloidosis presenting with multiple nodules in the tongue is reported. A 70-year-old woman with a history of chronic renal insufficiency and receiving long-term hemodialysis complained of tenderness along the margin of her tongue. Clinical examination and palpation demonstrated multiple, firm ash-yellow nodules. Microscopic examination of a biopsy specimen stained with alkaline Congo red revealed orange staining. Under a polarization microscope, green disdiaclast refraction of amyloid proteins was identified. The histopathological diagnosis of the specimen was amyloidosis. The patient has not noticed any symptoms after biopsy and is currently being observed.
