A case of Frey syndrome developing in the mandibular region after the removal of recurrent ameloblastoma including the submandibular gland is presented. The patient was a 63-year-old man who presented with gustatory sweating at the left mandibular region. He had undergone partial mandibulectomy and immediate reconstruction with alumina ceramics for an ameloblastoma arising in the left mandibular angle in 1986. The mandible was again reconstructed by iliac bone because of fracture of the alumina ceramics in 1987. The ameloblastoma recurred in the left submandibular region and was extirpated with the left submandiblar gland in 1995. After a few uneventful years, gustatory sweating developed at the left mandibular region in 2001. Frey syndrome of the left mandibular region was diagnosed by Minor's test. Frey syndrome in our patient was attributed to severe damage of the platysma and subcutaneous nerve due to repeated surgeries.