高カルシウム血症を呈した肺転移悪性エナメル上皮腫の1例

抄録

The patient was a 51-year-old woman. She was referred to the Department of Respiratory Medicine at our hospital because of a persistent cough. Our department was consulted about a mandibular ameloblastoma in relation to the treatment of her pulmonary lesions. She had suffered from ameloblastoma of the right side of the mandible had undergone enucleation at another hospital in December 1975. Subsequently, a total of 5 operations for ameloblastoma of the mandible were performed over the course of 12 years. Lung metastasis was found in February 2001. In addition, the patient had hypercalcemia probably due to an elevated circulating level of parathyroid hormone-related protein (PTHrP) caused by the metastatic ameloblastoma. We report a rare case of pulmonary metastatic malignant ameloblastoma with hypercalcemia due to PTHrP production.