Glandular odontogenic cyst (GOC) was first proposed by Gardner et al in 1988 as an infrequent developmental epithelial cyst occurring in jaw bones. We describe our experience with a case of GOC arising in the mandible and report the clinical course. The patient was 52-year-old woman with clearly bordered multilocular radiolucent lesions in bothsides of the mandibular premolar region. These cysts were extirpated, and the specimens were studied by routine pathological examination and immunohistochemical staining with cytokeratins. The diagnosis was established to be GOC. The cyst recurred 3.5 years after surgery, and reoperation was performed.