Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
A case of refractory recurrent osteosarcoma of the maxilla
Yukio YAMANOHiroki BUKAWAAkiyuki MURANOAkiko KAWABATAKatsuhiro UZAWAHideki TANZAWA
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2007 Volume 53 Issue 11 Pages 672-676

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Abstract

Osteosarcoma arising in the jaws is very rare, accounting for only about 7% of all osteosarcomas. A combination of chemotherapy and surgery has been reported to improve the survival rate of patients with osteosarcoma. We describe a case of locally aggressive osteosarcoma arising in the maxilla of a 51-year-old woman that recurred after operation and irradiation with carbon ions.
CT scans revealed a huge tumor, destroying the middle skull base and invading the right temporal lobe.
At presentation, the case was evaluated to be inoperable by a brain surgeon. Therefore, we performed high-dose methotrexate (MTX) citrovorum factor therapy combined with doxorubicin hydrochloride (DXR), cisplatin (CDDP), ifosfamide (IFM), vindesine sulfate (VDS), carboplatin (CBDCA), and caffeine (CAF). The tumor responded remarkably to chemotherapy, but proliferated again after the ninth course of chemotherapy. To maintain the patient's quality of life (QOL), partial resection was done 4 times with salvage chemotherapy. This regimen for chemotherapy was considered effective against osteosarcoma of the maxilla. The importance of standard treatment for osteosarcoma, including neoadjuvant chemotherapy, tumor resection, and adjuvant chemotherapy, was suggested.

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© Japanese Society of Oral and Maxillofacial Surgeons
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