Short Communications
The AMPA-Receptor Antagonist YM90K Reduces AMPA Receptor-Mediated Excitotoxicity in Rat Hippocampal Cultures
1998 年 76 巻 1 号 p. 105-108
詳細
1998 年 76 巻 1 号 p. 105-108
The effects of YM90K on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity were investigated using kainate, AMPA and cyclothiazide in rat hippocampal cultures. YM90K had neuroprotective actions against both kainate toxicity and cyclothiazideenhanced AMPA toxicity. YM90K induced a parallel and rightward shift of both kainate and AMPA dose-response curves. The application of YM90K even 3 hr after the start of kainate exposure significantly reduced kainate toxicity. These results indicate that YM90K protects neurons against AMPA receptor-mediated toxicity at an agonist site on the AMPA receptor and that YM90K protects against AMPA receptor-mediated toxicity even if applied after neurotoxic insult.
