2014 Volume 59 Issue 2 Pages 453-463
Introduction: An increase in the level of plasminogen activator inhibitor-1 (PAI-1) may be a factor related to coronary artery disease, which can be a cause of sudden death during exercise. The aim of this study was to evaluate whether a difference in the ratio of low-density (LDL-C) to high-density (HDL-C) lipoprotein cholesterol (L/H ratio) might affect the PAI-1 level during acute strenuous exercise.
Subjects and Methods: Thirteen healthy trained men aged 19 to 23 years participated. Seven were categorized as having a L/H ratio of <2.0 (L/H <2.0 group), and 6 as having a L/H ratio of ≧2.0 (L/H ≧2.0 group). Venous blood samples were collected from the subjects before and after they had performed the Cooper 12-min test (running as far as possible within 12 min). LDL-C concentration (mg/dL), HDL-C concentration (mg/dL), and PAI-1 level (ng/mL) were measured using blood samples.
Results: The PAI-1 level before (30.4±1.9 ng/mL) and after (25.8±3.4 ng/mL) exercise did not change significantly in the L/H <2.0 group, whereas it increased significantly in the L/H ≧2.0 group (41.1±10.0 ng/mL to 61.8±11.7 ng/mL, p<0.05).
Conclusions: The present study revealed that the PAI-1 level increased significantly after acute strenuous exercise only in the high L/H ratio (≧2.0) group.