Abstract
A one year-old boy with non-Hodgkin's lymphoma (abdominal primary, Stage IV) showed dissemination of the testes, bone marrow and central nervous system (CNS) at the time of diagnosis. During systemic induction chemotherapy, the patient manifested hypopyon in the left eye. An aspiration smear of the hypopyon confirmed the infiltration of lymphoma cells. For this eye lesion, we applied chemotherapy combined with high doses of methotrexate (MTX), which was effective to induce remission. Subsequent relapses in the bone marrow and CNS have been conquered, and the patient is in remission 12 months after the onset of NHL (10 months from the onset of hypopyon). High doses of MTX are believed to be useful for treatment of lymphomatous lesions in the anterior chamber of the eye, which is considered to be one of the pharmacological sanctuaries.
