携帯電話のWEBアクセス機能を活用した処方薬間相互作用判定システムの構築

抄録

A large amount of drug information is now available on the internet and patients' needs for drug information are becoming greater, especially with regard to adverse drug reactions, efficacy and drug interactions (DIs). However, it is difficult for patients to learn about all possible drug interactions for the drugs that they have been prescribed. With this in mind, we developed a drug-drug and drug-food/drink interaction appraisal system for individual prescriptions utilizing web access functions embedded in mobile phones.
The database on DIs was developed using Microsoft^® Access 2003. Three database master files were created : “Prescription Drug Substance Master”, “Prescription Drug Brand Name Master”, and “Drug Interaction Master”. Excepting Prescription Drug Substance Master, the master files were sent to a server configured using Linux OS, MySQL, Apache^®, and Hypertext Preprocessor (PHP). The database contains detailed information on 281 DIs, and 1064 entries for drug brand names and foods/drinks. It may be accessed from mobile phones, and its web pages were designed to be compatible with mobile phone operations.
Through the use of the present DI appraisal system, it is possible to easily retrieve information on drug-drug or drug-food/drinks interactions using drug brand names. When entering data and updating the system, the people who maintain the database are able to not only input specific drug names but also pharmacological classifications for defining DIs. Furthermore, information on DIs is provided using comprehensive terms to make it easy for the general public to understand.
In conclusion, by providing comprehensive information on DIs, the present DI appraisal system based on mobile phone access should raise patient awareness of DIs and can help to avoid them.