プラバスタチンからアトルバスタチンへの切り替えによる血清コレステロール値への影響

抄録

Patients were followed up for serum lipid levels after we changed their prescriptions from pravastatin to atorvastatin at our hospital. There was no significant decrease in the serum lipid levels of 17 patients who completed the follow up period on atorvastatin. However, replacing pravastatin with atorvastatin lowered total cholesterol (TC) levels from 260.9 mg/dL, a decrease of about 20% and a significant difference (p<0.0001). LDL-cholesterol (LDL-C) levels dropped from 162.1 mg/dL to 122.5 mg/dL, about 29% less and also a significant difference (p<0.0001). Triglycerides (TG) were lowered from 162.2 mg to 115.5 mg/dL, also about 29% less and again a significant difference (p<0.005). There was also a significant drop in HDL-cholesterol (HDL-C) from 66.3 mg/dL to 63.5 mg/dL (p<0.005) but this was in the normal range.
Atorvastatin seemed to be effective for treating patients in whom pravastatin had been considered ineffective. Further, since atorvastatin should be good at lowering TG levels, it may be effective when used selectively in treating patients with high levels of both LDL-C and TG.