医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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保険薬局におけるポピュレーションファーマコキネティクス解析の有用性評価
―オランザピンの投与量に及ぼす喫煙と性差の影響―
佐藤 弘希丸山 徹小田切 陽子三村 絵美子河上 恵子池田 倫子岡山 善郎安楽 誠小田切 優樹
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2006 年 32 巻 9 号 p. 940-945

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The results of a population pharmacokinetic (PPK) analysis for Japanese suggest that smoking and gender difference are factors influencing the clearance of olanzapine, an atypical antipsychotic drug. However, no post-marketing verification has been conducted regarding how these factors affect the prescribing of this drug by practicing physicians. We therefore conducted a retrospective analysis on the effects of smoking and gender difference on olanzapine dosages. The results showed that smokers received significantly higher doses of olanzapine than non-smokers and that males tended to receive higher doses of olanzapine than females. The dosage for male smokers, the highest dose group, was 1.3 times that for female non-smokers, the lowest dose group. These results showed good correspondence with those of the PPK analysis given in the package insert and suggests that PPK data could be useful information for the community pharmacist.

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© 2006 日本医療薬学会
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