医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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プレフィルド型インスリン注入器ソロスター®のゴム栓の性状および注入デバイスとしての構造上の問題点に関する一考察
朝倉 俊成清野 弘明影山 美穂影向 範昭
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2008 年 34 巻 9 号 p. 898-903

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To examine the properties of the rubber stopper of the newly-developed prefilled insulin injector,Lantus® SoloSTAR® (Sanofi Aventis ; hereinafter referred to as SOL),and its structural problems in relation to dose setting and injection accuracy,we performed certain basic testing in which the prefilled insulin pen Levemir® FlexPen® (Novo Nordisk Pharma Ltd.; hereinafter referred to as L-FLX) was used as a control.The testing consisted of measuring the dose setting knob torque,assessing the damage to rubber stoppers,measuring elastic properties,observing the fit of rubber stoppers in insulin cartridges and determining injection resistance patterns.Based on the results,we feel that attention should be drawn to the following points regarding the use of SOL for insulin injection :
1)Since clutch parts will easily wear out if the dose setting knob of SOL is rotated vigorously,the dose setting should be made gently and if patients feel uncomfortable with the torque needed to rotate the dose setting knob,they had better not use this product.
2)Any dripping or leakage from SOL would cause great anxiety in patients,and reduce injection accuracy.So if dripping is experienced,patients should be instructed to stop using this product.

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© 2008 日本医療薬学会
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