2010 年 36 巻 1 号 p. 51-56
In order to provide useful information on insulin self-injection to patients with diabetes mellitus,the physicopharmaceutical properties of insulin injectors and needles were investigated.
Humalog® Luxur/Humalog® Cart (HLL),Novopen® 300/Novorapid® 300 (NPR),Rantas Opticlic® /Rantas® (OPC),Humalog® Kit (HLK),Novo Rapid Frex Pen® (NRF) and Rantas Solostar® (SOL) were investigated as insulin injectors.
The amount of insulin actually infused,when various injectors were set to inject 10units was evaluated.For each injector,variability in the amount infused showed a tendency to decrease gradually,evaluation of the time-course of changes in infusion resistance was important for the comparison of injectors.Despite equal viscosity,levels infusion resistance of SOL was 20% of that for OPC and the infusion resistance of HLL became 75% of that for HLK.The infusion resistance with a 30G needle decreased compared those of 31G and 32G needles.The penetration stress of a 30G needle was approximately twice that of a 32G needle.The penetration stress of the needle was proportional to the strength.
When selecting an insulin injector,it is necessary to choose the device most suitable to the patient’s needs.