医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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向精神薬と転倒·転落の関係に関する研究
重山 昌人田口 真穂前山 直樹柚原 初美安里 昌順長田 成巨可知 敏明藤田 康平
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2011 年 37 巻 1 号 p. 49-55

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It is well known that psychotropic drugs,such as hypnotics and anxiolytics,increase the risk of falls for patients (includingfalls from high places).The present study was undertaken to evaluate the risk of falls following the taking of suchdrugs,with the focus on the benzodiazepine (BZ) family of hypnotics and anti-anxiety drugs previously reported to have ahigh risk of causing falls.When drugs of the BZ family were classified according to tmax,the mean frequency of falls differedbetween short tmax drugs and the long tmax drugs (P <0.05).This suggests that we should avoid combining shorttmax drugs (flunitrazepam,brotizolam,and triazolam) with other medication as well as the combined use of short tmaxhypnotics and drugs having potent muscle relaxant activity (bromazepam,diazepam,etizolam etc.) unless there is good justificationfor doing this.Our study showed that quazepam and rilmazafone hydrochloride are relatively safe hypnotics so far as the risk of falls isconcerned,in view of their relatively long tmax and less potent muscle relaxing activity.In some cases,the t1/2 of the drugswas correlated with the frequency of falls,suggesting that t1/2 may be a useful indicator for identifying patients requiringspecial attention and care from nurses,for instance when they are on night patrols of wards.

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© 2011 日本医療薬学会
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