2015 年 41 巻 11 号 p. 821-826
This study investigated the influence of treatment with statins on the effect of sitagliptin in obese patients with diabetes.
We studied 52 patients with type 2 obese diabetes who were started on sitagliptin from April 1, 2010 to March 31, 2012. Of these patients, 31 were taking a statin and 21 were not. HbA1c levels were measured at 0 and 3, 6, and 9 months after initiation of sitagliptin.
In obese patients (BMI ≧ 25 kg/m2), a significant improvement in HbA1c levels was observed only in those taking statins.
Our findings suggest that statins may modify the glucose-lowering effect of sitagliptin in obese patients with type 2 diabetes.