医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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肥満糖尿病患者におけるシタグリプチンの効果に及ぼすスタチンの影響
尾上 由華髙瀬 尚武合田 俊一米澤 圭祐新免 徹塩江 真代三木 育子中田 日早枝小畑 利之高原 典子室井 延之
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2015 年 41 巻 11 号 p. 821-826

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This study investigated the influence of treatment with statins on the effect of sitagliptin in obese patients with diabetes.
We studied 52 patients with type 2 obese diabetes who were started on sitagliptin from April 1, 2010 to March 31, 2012. Of these patients, 31 were taking a statin and 21 were not. HbA1c levels were measured at 0 and 3, 6, and 9 months after initiation of sitagliptin.
In obese patients (BMI ≧ 25 kg/m2), a significant improvement in HbA1c levels was observed only in those taking statins.
Our findings suggest that statins may modify the glucose-lowering effect of sitagliptin in obese patients with type 2 diabetes.

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