Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
Notes
Solubility Estimation for Drugs Treated with the Simple Suspension Method Using Available Dissolution Test Profiles
Wataru SakuradaTetsuya ShimoyamaKunihiko ItohMichiya Kobayashi
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JOURNAL FREE ACCESS

2015 Volume 41 Issue 8 Pages 540-549

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Abstract

The simple suspension method (SSM) is a method of administering drugs via feeding or gastrostomy tubes to those who have difficulty swallowing. In the SSM, solid formulations (eg, tablets, capsules) are immersed in hot (55℃) water. This promotes the disintegration and dissolution of the drugs and changes their solubility. However, pharmaceutical companies have not issued test results on the solubility and dissolution behaviors of suspended drugs prepared according to the SSM.
For this study, we chose 10 drugs, 8 listed and 2 not listed in the Japanese Orange Book, to compare the dissolution behaviors of each drug, treated vs untreated with the SSM. Dissolution was classified into three patterns: rapid (gliclazide and famotidine), moderate (propranolol, pindolol, metoprolol), and slow (furosemide, ibuprofen, glimepiride). The initial dissolution rates of the moderate-dissolution drugs increased markedly by employing the SSM. In this study, hydroxyzine capsules and phenytoin tablets, neither of which is listed in the Japanese Orange Book, were compared with different dosage/administration forms of those drugs listed in the book (ie hydroxyzine tablets and phenytoinphenobarbital combination tablets). The dissolution behavior of these drugs was not estimated from the dissolution profiles of different forms available in the book. Nevertheless, it seemed that the available data on the dissolution of drugs will be useful when pharmacists estimate the dissolution behavior of drugs administered using the SSM.

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© 2015 Japanese Society of Pharmaceutical Health Care and Sciences
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