Abstract
One of the serious adverse effects of the antithrombotic agents is intracerebral hemorrhage (ICH). We aimed to evaluate whether antithrombotic agents influence the outcome at the time of hospital discharge in patients with acute phase of ICH. Of the 353 patients with acute phase of ICH, 90 (25.5％) had been treated with antithrombotic agents. Modified rankin scale (mRS) at the time of hospital discharge in patients taking antiplatelet plus antithrombotic agents (combined antiplatelet and anticoagulant therapy: Combined) was higher than those taking antiplatelet agents only (single antiplatelet therapy: SAPT) or anticoagulant agents only (single anticoagulant therapy: SACT). Multiple logistic regression analysis showed that male sex [odds ratio (OR), 2.670; 95% confidence interval (CI), 1.115 - 6.392; P = 0.027)], hemodialysis (OR, 4.165; 95%CI, 1.572-11.033; P = 0.004), Combined (OR, 10.145; 95%CI, 2.520-40.849; P = 0.001), D-dimer > 1.9 μg/mL (OR, 5.271; 95%CI, 2.327-11.942; P < 0.001), NIHSS ≧ 15 (OR, 4.627; 95%CI, 1.888-11.339;P = 0.001) were associated with the death at the time of hospital discharge. This study shows that the onset of ICH taking Combined is associated with an increased risk of death.
