Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
Notes
Identification of the Risk Factors for Severe Neutropenia Induced by Pemetrexed Plus Carboplatin Chemotherapy
Ryosuke ArakiYasutaka TsukadaRyuichi HishinumaTakayuki KeiraKanae KatoTsuneaki Tanaka
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2016 Volume 42 Issue 4 Pages 278-285

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Abstract

Pemetrexed plus carboplatin chemotherapy has shown efficacy as a first-line treatment for advanced non-small cell lung cancer. However, severe neutropenia has often been reported as a serious adverse effect after the administration of this combination chemotherapy. Various risk factors associated with severe neutropenia induced by pemetrexed plus carboplatin chemotherapy have not yet been clarified. To clarify the risk factors associated with induced severe neutropenia by pemetrexed plus carboplatin, we retrospectively reviewed the records of 42 patients who had received first-line treatment with this combination chemotherapy at Yamato Municipal Hospital between April 2011 and May 2015. Of the 42 patients, 11 (26.2%) developed grade 3 or 4 neutropenia. Multiple logistic regression analysis showed that the creatinine clearance rate (CCr) of between 45 and 66 mL/min [odds rate: 11.00, 95% confidence interval (CI): 1.26-95.94, P = 0.030] and the co-administration of proton pump inhibitors (PPIs) [odds rate: 9.16, 95% CI: 1.02-82.48, P = 0.048] were significantly related to severe neutropenia in patients treated with pemetrexed plus carboplatin chemotherapy after adjustment with use of non-steroidal anti-inflammatory drugs and body surface area. Therefore, patients with moderately impaired renal function (45 mL/min ≤ CCr < 66 mL/min) or co-administration of PPIs may be risk factors for the development of neutropenia induced by pemetrexed plus carboplatin chemotherapy.

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© 2016 Japanese Society of Pharmaceutical Health Care and Sciences
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