Lisinopril tablets in the shape of a butterfly have been marketed. This unique tablet shape is the first of its kind. We evaluated the butterfly-shaped tablet, with respect to its distinguishability especially in appearance and its adaptability to the automatic tablet packaging machine equipped with a computer.The results showed that this tablet presents several advantages with regard to drug inspection, in giving instructions to patients for taking the drug and obtaining patients'compliance with such instructions.Moreover, this tablet could be put into small packages smoothly with the automatic tablet packaging machine.However, since the shape of the tablet is not a perfect butterfly, simply referring to the “butterfly-shaped medicine” may not be enough to convey the intended information.Therefore, some care should be taken.