病院薬学
Online ISSN : 2185-9477
Print ISSN : 0389-9098
γ-オリザノール (γ-OZ) を主薬とする細粒剤
平野 善信松永 幾郎杉木 欣司長谷川 健次北村 治栄古川 郁子尾崎 照美
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8 巻 (1982) 2 号 p. 119-123

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Drugs in fine granules are characterized by the minimum loss of components caused by dusting in dispensing, easy and uniform mixing with powdered drugs, and comparable bioavailability to powdered drugs. In this regard, 4 brands of γ-oryzanol preparation were tested for their physicochemical properties, mixing efficiency of γ-oryzanol with lactose, and dissolution rate. As a result, all the brands complied with the Particle Size Distribution Test of J. P. and the proposed test on flow behavior in terms of angle of repose, whereas the dispersibility was as high as 31% with one brand. The test on the uniform distribution by mixing test materials also showed a significant variation including CV value as high as 8% in one brand. The high CV value is a factor affecting the uniform distribution of γ-oryzanol due to the aggregation of this active component. The 4 brands were also tested for 50% dissolution time with three different test solutions. The values obtained were compared by a two-way analysis of covariance at.a significant level of 5%. Significant differences were observed among the brands, but not among the test solutions.

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