院内製剤アミノフィリン坐剤の直腸吸収

人における血漿および唾液中濃度

抄録

Theophylline concentrations in plasma and saliva after administration of three kinds of suppository and tablet were measured according to Schack and Waxier. Theophylline concentration with Witepsol base (Cmax 2.75μg/ml) was almost on a level with that with P. E. G. base (Cmax 2.81μg/ml) in respect to rectal absorption of aminophylline suppositories. Theophylline concentration of the suppositories (Cmax 2.40μg/ml) was lower than that of the aminophilline suppositories. Rectal absorption of the suppositories was slightly inferior to absorption by oral administration. Furthermore, a significant correlation was observed between the concentrations of orally administered theophylline in plasma and saliva.