多種のインスリン自己注射専用針とインスリン製剤のゴム栓の組み合わせによるコアリングの発生頻度

抄録

The cause of coring was researched using a combination of 6 types of injection needles and 5 types of rubber stoppers. The research was carried out by sticking a needle into a rubber stopper 30 times, and observing the core in the vial and also observing the interior of the stopper. As a result, the rubber stopper with the least amount of coring was the newly developed S 2-210N1. However, depending upon the needle used, coring occurred and protrusions and cracks in the rubber were confirmed in the interior of the rubber stopper. The best injection needle was found to be the PenNeedle 31G (PN 31 G needle). However, coring occurred when used with the rubber stoppers PenFill R 300U and HumaCart R300, which are currently sold on the market. The least amount of coring occurred with the combination of the S 2-210N1 and the PN31G. In addition, while an extreme amount of coring occurred with a MicroFine Plus 31G (BD31G needle) cut needle tip, little coring occurred with the non-cut needle tip, and it was discovered that the make-up of the needle tip of the injector is closely related to such coring. The cause of the core occurrence was thus found to be the make-up of the needle tip and the material of the rubber stopper. In addition the affinity of both parties is also related. Therefore, in order to prevent coring it is advisable to change the rubber stoppers of insulin medicine to a rubber that does not cause coring, and to use an injection needle with a make-up close to the PN31G needle. In addition, the rubber stopper and needle combination for such usage needs to be further evaluated.