医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
ナフトピジル製剤の光安定性
竹下 光弘千葉 貴志上井 幸司久道 周彦佐々木 直子浜谷 孝郎
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2005 年 31 巻 6 号 p. 464-469

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Some medicines are known to decompose due to the influence of temperature, moisture, or light and the resulting deterioration in their quality may cause unexpected serious adverse reactions in patients. In this study, we exposed various forms of naftopidil to light and determined any changes in quality from their appearance, TLC and 1H-NMR spectrum. The results showed that the degree of decomposition depended on the form of the drug, the wavelength of the light and duration of exposure to light.

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