In this brief review, we have discussed the functional significance of cardiac myosin isoform redistribution. The development of in vitro motility assay techniques has greatly aided the research in this field. The next important step would be the integration of data at molecular or cellular level to account for the pathophysiology of animal or human body. A new conceptual framework that can deal with the complex nature of a biological system may be required for this purpose.
1998 by The Physiological Society of Japan