The Japanese Journal of Physiology
Print ISSN : 0021-521X
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Does Higher Red Blood Cell (RBC) Lactate Transporter Activity Explain Impaired RBC Deformability in Sickle Cell Trait?
Philippe Connes, Fagnété Sara, Marie-Dominique Hardy-Dessources, Maryse Etienne-Julan, Olivier Hue
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Keywords: hemorheology, sickle cell trait, lactate
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2005 Volume 55 Issue 6 Pages 385-387

View "Advance Publication" version (January 31, 2006).
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Abstract

Lactate and H+ are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.

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© 2005 by The Physiological Society of Japan
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