Augmentation of Catecholamine-stimulated [³H]GDP Release in Adipocyte Membranes from Exercise-trained Rats

Abstract

The effects of exercise training on the catecholamine-stimulated [³H]GDP release in rat adipocyte membranes prelabeled with [³H]GTP and the adenylate cyclase activity were investigated. Exercise training significantly increased the release of [³H]GDP in response to (-)isoproterenol. The adenylate cyclase activity induced by a nonhydrolyzable guanine nucleotide analogue, Gpp(NH)p, was significantly greater in exercise-trained rats.