1978 Volume 44 Issue 4 Pages 509-518
N-(3', 5'-dichlorophenyl)-1, 2-dimethylcyclopropane-1, 2-dicarboximide, procymidone (S-7131, Sumilex(R)) inhibited increase in hyphal cell number of Botrytis cinerea preceding inhibition of increase of hyphal dry weight.
Oxygen consumption of the mycelium was hardly affected. Procymidone curtailed increase in protein, RNA and DNA contents at the rates approximately corresponding to that of inhibition of dry weight increase. The incorporation of 3H-uridine into acid-soluble and acid-insoluble fractions of the cells was more rapidly and strikingly inhibited. The effect on uridine incorporation may be ascribed to disturbance of membrane function for the transport. Procymidone moderately affected the incorporation of 14C-acetate into total lipids and did not specifically inhibit the synthesis of individual lipid class. The synthesis of the cell wall was stimulated by the treatment of procymidone without marked change in its constituents. Though the primary site of action of procymidone is still obscure, it is supposed that procymidone may act on cytoplasmic membrane and its action must be related to membrane function for the transport and cell wall synthesis.