Abstract
Neuroimaging studies on Eating disorder patients have been done recent years. We evaluated histamine H1 receptor binding potential in female patients with anorexia nervosa (AN), healthy men and women. Healthy women showed higher binding potential in bilateral orbitofrontal cortices, right temporal cortex, bilateral amygdalas, and bilateral hippocampi than men. AN showed higher binding potential in right amygdala and left lentiform nucleus than healthy women. These differences may be relevant to pathogenesis and maintenance of AN. We administered the Wisconsin Card Sorting Test to AN and healthy women, and recorded brain blood flow change during the task with fMRI. AN showed poorer brain activity in right ventrolateral prefrontal cortex and bilateral parahippocampal gyri than healthy women. Ventrolateral prefrontal cortex is activated during judgement. Parahippocampal gyri play a role in prediction of future events. ANs' judgement and prediction may be impaired. Neuroimaging studies of eating disorder will make a breakthrough to elucidation of the disease.
