2007 Volume 20 Issue 1 Pages 31-34
We reported a 14 years old girl with TINU syndrome. At the onset of uveitis, she presented renal glycosuria, pyuria, and insufficiency of urinal concentration. Elevated serum creatinine level and urinal β2 microglobulin (β2MG) excretion were also found in the laboratory test. The renal biopsy showed significant inflammatory cell infiltration in the interstitium but no morphological change of glomeruli, which findings were considered those of acute interstitial nephritis. As the result of informed consent to the patient, we decided to observe the natural course without giving systemic steroid therapy. Then the serum creatinine level and urinary β2MG excretion decreased gradually and recovered within the normal range after 8 months.
The renal symptom of this case was improved without systemic steroid therapy. This case suggests that we should observe the renal symptom of TINU syndrome without aggressive systemic steroid therapy, as long as any of rapid deterioration of renal function or systemic symptom is not present.
