Japanese journal of pediatric nephrology
Online ISSN : 1881-3933
Print ISSN : 0915-2245
ISSN-L : 0915-2245
Case Reports
Clinical usefulness of rituximab for early remission in anti-neutrophil cytoplasmic antibody associated vasculitis: a case report
Hitoshi IrabuShuya KanekoNatsumi InoueMao MizutaKazuyuki UenoMasaki ShimizuAkihiro Yachie
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2021 Volume 34 Issue 1 Pages 39-44

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Abstract

A 12-year-old girl with hematuria and proteinuria in school urinary screening was referred to us. Physical examination revealed no extrarenal lesions. Laboratory findings revealed impaired renal function and the elevation of serum MPOANCA (anti-neutrophil cytoplasmic antibody) level. Kidney biopsy showed necrotizing crescentic glomerulonephritis. From these findings, ANCA associated nephritis was made. Early remission was achieved with the combination treatment of methylprednisolone pulse therapy and rituximab. Long term remission without severe complications has been achieved with the maintenance treatment with the combination of prednisolone and azathioprine. Rituximab might be useful to achieve early remission in ANCA associated nephritis.

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© 2021 The Japanese Society for Pediatric Nephrology
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