2003 Volume 21 Issue 3 Pages 231-238
In the present study, effects of the entorhinal and hippocampal lesions on delayed non-matching-to-place (DNMTP) performance in radial maze were examined to investigate the differential involvement of the entorhinal cortex and hippocampus in place guided working memory. Rats with lesions of the entorhinal cortex displayed significant delay-dependent impairments on DNMTP performance, whereas the performance of the hippocampal lesioned rats was severely impaired for all the delays examined. The results indicate that the entorhinal cortex is primarily involved in place guided working memory, and the hippocampus has involvement with reference memory in addition to place guided working memory. Therefore, these findings suggest that there is a functional dissociation between the entorhinal cortex and hippocampus.