Volume 49 (2016) Issue 1-2 Pages 17-25
Various types of adherent eukaryotic cells perform amoeboid locomotion. Until recently, it had been thought that the motive force of the locomotion was mainly produced by polymerization of actin at leading edge. However, more recently, another mechanism has been proposed. The mechanism is called bleb-driven amoeboid locomotion, typically seen in the locomotion of a giant-free-living amoeba, Amoeba proteus. The motive force of the locomotion is intracellular hydrostatic pressure, which is produced by contraction of the cell cortex actomyosin. In this review, we describe the mechanism of bleb-driven amoeboid locomotion through recent studies.