抄録
The purpose of this study was to clarify how different components of biomaterials affect cell activities of osteoblasts. In this experiment, osteoblasts were cultured on titanium and bioactive glass, and the intracellular free calcium ([Ca2+] 1) that plays an important role in the intracellular signalling system was measured. In the early stages of the culture, the osteoblaststended to increase [Ca2+], when cultured on bioactive glass more than on titanium. This indicated that direct contact of osteoblasts to bioactive glass was essential to generate theobserved effect on [Ca2+] 1. Furthermore, elevation of [Ca2+] 1 did not occur whenextracellular calcium was supplied. These results suggested that bioactive glassaffects the intracellular signalling system of the osteoblasts when in contact with bioactive glass
