1993 年 31 巻 2 号 p. 269-280
The long term Erythromycin (EM) therapy has been reported as useful in chronic respiratory tract disease including chronic sinusitis. We investigated the clinical effects of long term EM derivative, Clarithromycin (CAM) therapy for chronic sinusitis. Twenty-three adults were treated with 400mg of CAM per day and 11 children were treated with 100 or 200mg of CAM per day for 4 to 12 weeks.
1) Total improvement rate of symptoms and rhinoscopic findings were estimated in 56.5% of adults and in 72.7% of children.
2) The Saccharin time was examined before and after the therapy. The CAM therapy reduced significantly the saccharin time, namely CAM improving mucociliary transport function.
3) The clinical effects depended on the term of the therapy within 12 weeks. Longer therapeutic term which exceeds 12 weeks may improve the clinical results.
4) The clinical effects tended to appear earlier in the CAM therapy than in the EM therapy.
5) No significant side effects were noted during the therapy.
EM derivative, CAM was useful for the treatment of chronic sinusitis as well as EM.