慢性副鼻腔炎に対するネブライザー療法

治療効果をたしめる使用機器と使用法

抄録

From the point of view that the naso-paranasal sinus is a single organ, the fundamental and clinical experiments were performed to examine the instruments making the nebulizer therapy for paranasal sinusitis more effective, and how to use, and the following results were gained.
1. According to the experiment that the deposition parts of aerosol particles were examined of a pig ment in the human modeled nasal cavity and of a Tc-isotope in the nasal cavity of heal-thy adults, the instruments of the jet and the ultrasonic nebulizer gave the most steady deposition of aerosol particles at the middle nasal meatus in various kinds of nebulizer instruments on the market.
2. If the case is that the ultrasonic nebulizer therapy can improve the lesion of the middle nasal cavity, it can also improve the lesion of the paranasal sinusits.
3. After making the middle nasal meatus open by improving its lesion by the nebulizer therapy or the operation, the deposition concentration of the used drug at the maxillary sinus mucosa was higher than that in the case of the unopened middle nasal meatus.
4. The histolgical improvement of the paranasal sinus muxosa injuried by experimental allergic paranasal sinusitis was demonstrated both light and electron microscopically after the ultra-sonic nebulizer therapy of steroid.
5. The nebulizer instrument with adding a pressure showed a lower deposition rate but a larger amount of deposit in the paranasal sinus than that with both a pressure and a vibration.
6. According to the comparative study of the radiolucency of the X-ray shadow of the maxillary sinus before and after the nebulizer therapy with or without adding a pressure for paranasal sinusitis, the nebulizer therapy with a pressure showed a significantly higher rate of improvement.
7. From the above results, after improving the lesion of the middle nasal meatus by the jet or the ultrasonic nebulizer therapy or by the operation, the further nebulizer therapy can improve the lesion of paranasal sinusitis. Moreover, the nebulizer instrument with adding a pressure can give more deposit of drugs in the paranasal sinus and make the lesion of paranasal sinusitis more impro ved.